10. PTC: Cancer Types: Skin

10. PTC: Cancer Types: Skin

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2020 01 31 111734

"If you see something on your skin that is new, changing, not healing or doesn’t seem right, get it checked out as soon as possible"

 2020 09 11 104538

What is skin cancer?

Skin cancer occurs when skin cells grow out of control, often caused by ultraviolet (UV) radiation from the sun and UV tanning machines. The skin is the largest organ in the body. Skin cancer can be treated successfully if found early. The two most common types of skin cancer after transplant are basal cell cancer (BSS) and squamous cell cancer (SCC), however, there are other types of skin cancer including melanoma and Merkel cell carcinoma (MCC).
According to the American Cancer Society (https://www.cancer.org/cancer/skin-cancer.html) Cancer can start at any place in the body. Sometimes, skin cancer cells can spread to other parts of the body, but this is not very common. When cancer cells spread to other places, it’s called metastasis. To doctors, the cancer cells in the new place look just like the ones from the skin. Cancer is always named based on the place where it starts. So if skin cancer spreads to another part of the body, it’s still called skin cancer.
Additional ACS Sources:

 skin cancer screening

What are the risk factors for skin cancer? 

All transplant patients are at increased risk to develop skin cancer. However, transplant patients with the following characteristics are at greater risk for skin cancer. These characteristics include:
• Older individuals
• Men
• Fair and easily burned skin
• Freckled skin
• Blue, green or hazel eyes
• Red and blonde hair
• People who have outdoor occupations or extensive exposure to the sun
• Family history of skin cancer
• Personal history of skin cancer


  How does skin cancer present?

  What symptoms should patients be on the lookout for?

Skin cancer presents itself in different ways, but there are many common warning signs. Overall, you should be looking for a change in your skin such as new skin lesions like a mole, growth, dark spot, itchy dry spot or sore that develops and does not go away. However, not all lesions mean you have skin cancer. The CDC says that people should watch for these symptoms – a helpful way to remember them is to call them the A-B-C-D-Es: 

  • Asymmetry: Does the spot or sore have two halves that are different shapes and sizes?
  • Border: Does the spot or sore have irregular or uneven edges?
  • Color: Does the spot or sore have an uneven color?
  • Diameter: Is the spot or sore larger than the size of a pea, or one-quarter inch?
  • Evolving: Is the spot or sore changing in size, color, or shape?

  What does skin cancer look like visually?




Remember that the three most common types of skin cancer are Basal Cell Carcinoma, Squamous Cell Carcinoma, and Melanoma.

  • Basal Cell Carcinoma: This cancer sometimes gets mistaken by people as a scar because they look really similar. This skin cancer is usually flat, and either flesh-colored, brown or yellow. This usually appears in places where you get a lot of sun like your face and neck. These can appear early on as a pearly or waxy bump with blue, brown or black areas.
  • Squamous Cell Carcinoma: This skin cancer can look like a rough or scaly spot that can crust over or bleed. It could also look like a lump or growth that is flatter in the middle and raised around the outside. It could also look like an open sore that is oozy or crusty. It could also look more like a wart but with different colors than a usual wart. Remember, these can happen in your mouth too.
  • Melanoma: This skin cancer can look like a large brown spot with darker spots inside of it. It is common for Melanoma to show up as a change in a mole you already have. This skin cancer could also look like a spot that has a border with a strange pattern. The border could be red, pink, blue, black or white. This skin cancer could feel like a spot that is itchy or burns, and it might only hurt when you scratch it.


How quickly does skin cancer develop after organ transplant?

The majority of fair-skinned organ transplant patients will eventually develop skin cancer. After a transplant, there is generally a lag time of 3-7 years before skin cancers begin to develop. This period of time may vary depending upon individual risk factors. The longer a person takes immunosuppressant medications and the higher the dose, the greater the risk of skin cancer. In temperate climates 40% of fair-skinned patients develop skin cancer within 20 years after transplantation. In warmer climates, up to 80% of fair-skinned patients develop skin cancer within 20 years after transplant.

For a quick photo introduction of what to look out for, link to this simple 7-slide view of skin cancer signs and symptoms (<-- just click here)

For more details, see the ITNS link below to their downloadable Skin Cancer booklet.

Action Plan

What are the treatments for skin cancer?
If caught early, skin cancers are almost always curable. Basal cell carcinomas and squamous cell carcinomas can be treated with a variety of methods including scraping and freezing for early skin cancers and surgical removal for more advanced cancers.

Melanoma is treated by surgically removing the growth. Mohs micrographic surgery is a special surgical procedure used to ensure the complete removal of a skin cancer, while sparing normal skin. Although the surgical removal of skin cancers inevitably leaves scars, appearance can usually be restored to a high degree after skin surgery.

There is more than one type of skin cancer

Skin cancer is simply an abnormal growth of skin cells and while they can all hurt your health, most aren't deadly, according to the American Academy of Dermatology. Melanoma is the one people most often hear about but it's far more common to get actinic keratoses (AK), basal cell carcinoma (BCC), or squamous cell carcinoma (SCC).

Melanoma is the number one cancer killer in younng adults

Melanoma is the least common type of skin cancer, accounting for just 1 percent of all cases, but it's got the highest fatality rate. Once it's spread to other parts of the body it has a 10 to 15 percent survival rate, according to the American Cancer Society. However, the rate of survival increases the earlier you get diagnosed—if it's caught before it reaches the lymph nodes, the survival rate is over 90 percent—so stay current on your check-ups.

 The other types aren't great for you either

Just because AK, BCC, and SCC aren't normally deadly, doesn't mean you shouldn't worry about them. People with squamous cell carcinoma have a higher risk of death from any cause than the general population, according to the American Academy of Dermatology. About 4,140 people will die from skin cancers other than melanoma in the United States this year, they add.

How to spot skin cancer

Click on the image below to view this article by the American Cancer Society:


Your risk of getting it is almost entirely under your control

Skin cancer is the most preventable and yet the most ignored cancer, Dr. Barr says. In fact, taking a few simple preventive measures can lower your lifetime risk of getting any type of skin cancer by nearly 80 percent, according to the Prevent Cancer Foundation.

Reduce your risk for skin cancer
Protection from ultraviolet (UV) radiation is important all year round, not just during the summer or at the beach.  UV rays from the sun can reach you on cloudy and hazy days, as well as bright and sunny days.  UV rays raise also reflect off of surfaces like water, cement, sand and snow
The CDC recommends easy options for protection from UV radiation:
  • Stay in the shade, especially during the midday hours
  • Wear clothing that covers your arms and legs
  • Wear a hat with a wide brim to shade your face, head, ears and neck
  • Wear sunglasses that wrap around block both UVA and UVB rays
  • Use sunscreen with a sun protection factor (SPF) of 15 or higher, and both UVA and UVB broad spectrum) protection
  • Avoid indoor tanning

Source: CDC.gov


Life Phases of Post-Transplant

updated: 9/18/2020     Note: we welcome your comments/suggestions via e-mail to GleasonJim@TRIOweb.org

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    DISCLAIMER: The content of this TRIO post-transplant cancer Web site is not influenced by sponsors. The site is designed primarily for use by transplant recipients and their supporters. The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for educational and informational purposes only. In no way should it be considered as offering medical advice. Please check with your transplant team or a physician skilled in cancer and your organ type if you suspect you are ill.